Youkilis hurt his hand diving and knocking down a grounder in the seventh inning of Tuesday night's win and was also hit by a pitch on the hand in Monday's game. Manager Terry Francona changed the lineup about an hour before Wednesday's first pitch. Drew Sutton took Youkilis' spot in the field.
A team spokesman did not know if Youkilis was being examined by a doctor. He was examined by trainers and has not had an X-ray as of yet.
Right fielder J.D. Drew was held out of the lineup on Wednesday as well
with a strained right hamstring. He made a nice running catch in foul territory in the ninth inning of Tuesday's game.
Drew was replaced by Mike Cameron on Wednesday. Francona said he didn't believe Drew's injury was serious.
In other Red Sox news, right-handed reliever Bobby Jenks, who has a right biceps strain, threw a bullpen session Wednesday. He's been on the disabled list since May 5.
Starter John Lackey, who has a right elbow strain, is scheduled to throw on the side in Detroit on Friday.
The Red Sox welcomed back second baseman Dustin Pedroia to the lineup on Wednesday. In his first at-bat, he drove a 3-1 pitch into the left-field bleachers for his third home run. He injured his right foot in the eighth inning of Monday's game and sat out Tuesday.
Information from The Associated Press and ESPNBoston.com contributor Bob Finnan was used in this report.