BOSTON -- The last time the Blue Jays faced Clay Buchholz, Edwin Encarnacion was left out of the starting lineup because of his career numbers against the Red Sox right-hander.
This time, the Toronto first baseman was too hot to sit.
"I don't think you can get any hotter than this," Blue Jays manager John Gibbons said Wednesday night after Encarnacion led Toronto to a 6-4 victory over Boston by hitting two homers off Buchholz -- his second straight multihomer game. "He erased all that, though."
More from ESPN.com
Edwin Encarnacion is having a huge month for the Blue Jays, but it's no secret he could have been anybody's bopper, David Schoenfield writes. Story
Clay Buchholz says he is fine physically, and that leaves the question of why he is struggling for the Boston Red Sox, Gordon Edes writes. Story
Entering the game with just one hit in 21 at-bats against Buchholz (2-4), Encarnacion hit a solo homer in the second inning and a two-run shot in the third. Encarnacion, who homered twice in Toronto's 7-4 victory Tuesday, now has seven homers in his past six games.
He is the first Toronto player to have four multihomer games in a month and the first major leaguer to do so since Troy Tulowitzki in September 2010.
"It's crazy how this game is," Encarnacion said. "In April, I only had two homers; now I have (11) this month and two in one day. That shows you how crazy this is."
Drew Hutchison (3-3) allowed one run in 5 1/3 innings for Toronto, which has won seven of its past nine games. Casey Janssen pitched the ninth for his fifth save.
Xander Bogaerts had three hits, including two doubles, as Boston lost its sixth consecutive game. It's the team's longest losing streak since dropping the final eight games of the 2012 season, ending the Bobby Valentine era after one year.
Buchholz allowed four earned runs in 4 2/3 innings, striking out two while walking two and giving up nine hits -- including two homers to a batter he had dominated.
"He's a dangerous hitter with tremendous power," Red Sox manager John Farrell said. "You make mistakes, he makes you pay. This is a quick-strike offense."
The Blue Jays made it 4-0 after three innings thanks to Encarnacion's two homers into the seats above the Green Monster. Shane Victorino homered for Boston -- his first since a grand slam in Game 6 of the American League Championship Series against the Detroit Tigers -- to make it 4-1.
Dioner Navarro's RBI single in the fifth made it 5-1 and chased Buchholz. The Blue Jays added another run in the seventh on Anthony Gose's RBI single.
A.J. Pierzynski, who was hitless in 11 straight at-bats, raised his hands to the heavens after singling in sixth inning. He had just two hits in his previous 27 at-bats. Pierzynski wound up with three hits in the game, including one off the first baseman's mitt, in the ninth inning. ... Encarnacion has 15 multihomer games in his career, four this season. ... Buchholz had allowed three earned runs or fewer in three of his previous four starts. ... SS Stephen Drew, who re-signed with the Red Sox on Wednesday after spending the first six weeks of the season as an unsigned free agent, was available to play in an emergency. He was added to the roster in the place of LHP Felix Doubront, who injured his shoulder and went on the disabled list.
Copyright by STATS LLC and The Associated Press
BOSTON, MA - MAY 21: Stephen Drew #7 of the Boston Red Sox and Xander Bogaerts #2 of the Boston Red Sox take...
36,116 (97.4% full) - % is based on regular season capacity
64 degrees, partly cloudy
Home Plate - Mark Ripperger, First Base - Gary Cederstrom, Second Base - Kerwin Danley, Third Base - Lance Barksdale
From Elias: Edwin Encarnacion: 1st player in Blue Jays history with 11 HR in 15-game span.
He's 3rd player with 11 HR in 15-game span that ended within the last 2 seasons-- joining Chris Davis (whose streak encompassed 2012 and 2013) and Domonic Brown