Lester gave up two runs and six hits in six innings. He had allowed just one earned run over 31 innings in his previous four starts.
"We made David work pretty hard, but he was able to get a lot more early-out counts than I was, and that's why he was able to go a couple more innings," Lester said.
The crowd greeted Ortiz with sustained booing before his first at-bat in the first. The fans then gave Price a partial standing ovation after Ortiz took a called third strike.
"Our fans were pretty hot," Maddon said. "They came out with a little attitude. We dug it."
Shane Victorino connected in the second for the 20th home run allowed this season by Price. Victorino also singled home Ortiz in the sixth.
Zobrist had infield singles in each of his first three at-bats. ... Rays OF Wil Myers (broken right wrist) hopes to take batting practice in four or five days. He could return in mid-August. ... Tampa Bay reliever Joel Peralta (illness) could come off the DL early next week. He will pitch for Class A Charlotte on Saturday. ... Rays C Ryan Hanigan (left oblique strain) ran the bases after defensive drills. ... Boston C Ryan Lavarnway (wrist) was sent to Triple-A Pawtucket to continue his rehab assignment. ... Tampa Bay plans to recall RHP Jeremy Hellickson (elbow surgery) from Charlotte to make his second big league start of the season Saturday night. The Red Sox will counter with RHP John Lackey.
Copyright by STATS LLC and The Associated Press
ST PETERSBURG, FL - JULY 25: David Price #14 of the Tampa Bay Rays pitches during the first inning against the...
Evan Longoria is hitting .193 this season in at-bats ending with a pitch on the inner third of the plate or closer, well below the league average of .263 and his lowest mark in a season since 2011 (.245). Jon Lester leads all qualifiers in percentage of pitches thrown in that zone to righties this season (49.9 percent).