Brady threw for another TD in the third quarter, matching his career high, before leaving the game. Backup Brian Hoyer ran it in from 1 yard to make it 59-0 -- a franchise record for points.
Hoyer also led the Patriots deep into Titans territory in the fourth, but New England turned the ball over on downs after a short pass on fourth-and-7.
The record for TD passes in an entire game is seven, by five players -- all before the NFL-AFL merger in 1970. Since then, 14 quarterbacks have thrown for six TDs in a game, including Brady against Miami in 2007.