Ramirez batted fifth as the designated hitter for the series finale against the Indians, which Chicago won 6-4. He grounded out to short in his first at-bat, and he struck out looking in the fourth. Ramirez notched his first hit with the White Sox with a bloop single in the seventh inning, and he was hit by a pitch in the eighth.
After the game, Ramirez addressed an issue that's been generating plenty of conversation as he said he's flying his personal barber to Boston and will have his hair cut -- per White Sox team policy -- before Friday's game against the Red Sox.
"It seems like everywhere I go, people worry about my hair," Ramirez told ESPN's Pedro Gomez. "I just want to go out there and play the game."
Ramirez's barber, Angel Pena -- nicknamed "Monster99" -- enjoys his own notoriety as the barber for several Major League Baseball clients, including White Sox manager Ozzie Guillen and New York Yankees shortstop Derek Jeter.
Ramirez joined the White Sox on Tuesday, but only got as far as the on-deck circle to pinch-hit in the ninth inning. As he was waiting to bat, A.J. Pierzynski hit a three-run, tiebreaking homer as Chicago won 4-3.
Guillen says he has no concerns about Ramirez fitting in with the sometimes chaotic White Sox, who entered Wednesday trailing first-place Minnesota by four games in the AL Central. The White Sox claimed Ramirez off waivers, hoping the slugger can help them reach the playoffs.
Some eyebrows were raised when Ramirez, who regularly conducts interviews in English, which he speaks fluently, decided to conduct his first interview as a member of the White Sox in Spanish. Guillen seemed to believe it's part of Ramirez's desire not to be the center of attention, although it might have had the opposite affect.
"Talking to him, I don't think Manny wants to come here and be a distraction," Guillen said Wednesday on "The Waddle & Silvy Show" on ESPN 1000. "Manny doesn't want to come here to be 'The Guy.'
"He respects Paul Konerko and all the players we have here. He doesn't want to be in the middle and talk about him. Believe me, he feels funny when people want to talk about him and not talk about the ballclub. He's just one guy going about his business. I don't care if Manny speaks English or Spanish, as long as his bat speaks for itself. That's all I care about."
And Guillen wasn't upset Ramirez didn't arrive in Cleveland until after 3 p.m. Tuesday, despite the fact the deal was done Monday afternoon.
"The last flight out of L.A., I don't know when it was, to be honest with you," Guillen said. "He was going to arrive here at 7 a.m. [Tuesday]. Then he made the decision to leave at 7 a.m. to arrive in Cleveland at 3 in the afternoon.
"Manny's not 2 years old. He's coming off the DL, and it's a long flight. We did it before. We did it with [Alex] Rios when he got to Seattle last year [after being acquired from Toronto]. We did it with Ken Griffey Jr. We're not that pressed to put Manny in the lineup yesterday. He was ready to pinch-hit. I talked to him about it. The first thing he told me was, 'Whatever you guys want to do, I'm willing to do it. You want to play me, that's fine with me.' But I didn't like the way he said it. I have to make sure I have him for the rest of the season."
Information from The Associated Press was used in this report.