Tinoisamoa had limited participation at practice on Tuesday.
The veteran linebacker started all nine games for the Bears this season, and he was playing well after an injury-plagued 2009. Tinoisamoa is sixth on the team with 46 tackles, and he has one sack, one forced fumble and four tackles for a loss.
Fourth-year linebacker Nick Roach will replace Tinoisamoa in the starting lineup.
Roach started 24 games the past two seasons at strong and middle linebacker, but suffered a knee injury in training camp and subsequently lost the starting job to Tinoisamoa. Roach tied for the team lead with 10 tackles for a loss last year and was fourth with 82 tackles.