Rangers trainers first visited Holland on the mound in the first inning, but the lefty remained in the game. He walked Delmon Young and J.J. Hardy to start the second inning, then gave up an RBI single to Nick Punto.
Pitching coach Mike Maddux went out to see Holland again, and he motioned to the trainers to return to the mound. Holland left the game, shaking his head and throwing his hands up as he walked to the dugout.
"I felt normal. They came out and asked me if I felt all right and I felt like everything was normal," said Holland, who will meet with team doctors in Texas on Monday. "It was just a little shoulder tightness and I'm going to find out what it is."
Holland gave up three runs, three hits and three walks. He entered the game with a 2-0 record and an ERA of 2.95.
Holland was replaced by left-hander Matt Harrison.