Dallas will be at Washington on Sunday, Sept. 12, at 7:20 p.m. in a game to be televised on NBC.
The Cowboys are coming off an 11-5 regular season and a first-round playoff victory over the Philadelphia Eagles. But a 34-3 rout by the Minnesota Vikings in the next round left a bad taste in Dallas' mouth.
The home crowd will get its first look at the 2010 version of the Cowboys on Sept. 19, when Dallas hosts the Chicago Bears at noon. The Cowboys travel to Houston the following week before heading into an early bye week.
The Cowboys get a rematch with the Vikings in Minnesota on Oct. 17. They appear on ESPN's "Monday Night Football" against the Giants the following week.
Dallas hosts the Super Bowl champion New Orleans Saints on Thanksgiving.
Two of the Cowboys' last four games are against NFC East rival Philadelphia.
In all, the Cowboys have five prime-time games, including Christmas night at Arizona.
"We knew before [Tuesday] that this was a very challenging schedule with seven games against playoff teams and two of those with the Super Bowl participants," said Cowboys owner and general manager Jerry Jones. "Seeing it on paper doesn't make it any easier, but our team will be ready. We're looking forward to it."