"It doesn't look like they're going to play," coach Wade Phillips said Friday.
Colombo and Kosier, who are both recovering from knee injuries, should be ready to return to practice next week before the Week 2 game against the Chicago Bears, Phillips said.
Colombo had arthroscopic surgery Aug. 16 to remove five loose particles from his right knee. Kosier suffered a sprained MCL in his right knee Aug. 18.
Phillips noted Kosier's recovery has gone faster than expected. but Colombo's recovery has gone a little slower.
In other injury news, rookie offensive tackle Sam Young (sprained MCL) will not play. ... Strong safety Gerald Sensabaugh (shoulder), listed as probable on the injury report, will start against the Redskins. He missed the final two preseason games.