It is the first time the Bruins have claimed the Presidents' Trophy since the 1989-90 season.
Cody Hodgson scored for Buffalo.
Sabres goalie Matt Hackett was taken from the ice on a stretcher after Boston defenseman Torey Krug fell on his right leg with 11:35 left. He was replaced by Connor Knapp, who allowed Krejci's second goal one minute later.
It is the second time the Bruins have won the Presidents' Trophy, given to the NHL team with the most regular-season points, since the award was instituted for the 1985-86 season.
FLYERS 4, PENGUINS 3, OT
Streit's backhand shot from the right circle caromed between Fleury's pads and into the net as the Flyers clinched third place in the Metropolitan Division.
Jakub Voracek scored twice for the Flyers, and Claude Giroux added his team-high 28th goal of the season. Ray Emery made 12 saves after replacing injured starter Steve Mason to start the third period.
Letang scored in the final minute of regulation to force overtime after Giroux gave the Flyers a 3-2 lead with 1:15 left.
CANADIENS 1, RANGERS 0, OT
MONTREAL -- Brian Gionta scored on a penalty shot at 2:04 of overtime to allow Montreal to finish the regular season with 100 points.
Carey Price made 41 saves as Montreal moved past Tampa Bay for second place in the Atlantic Division.
The Lightning can still claim home ice advantage for their first round playoff meeting versus Montreal with a victory on their final game Sunday against Washington.
The Rangers have home ice for the first round.
BLUE JACKETS 3, PANTHERS 2
SUNRISE, Fla. -- Ryan Johansen scored the tiebreaking goal in the third period to and Columbus beat Florida for the eighth straight time.
The Blue Jackets clinched the first wild-card spot and will face Pittsburgh in the first round of the Stanley Cup playoffs.
Philadelphia's 4-3 overtime win over Pittsburgh earlier Saturday clinched third place in the Metropolitan Division for the Flyers and forced Columbus to the wild-card spot.
Johansen's 33rd goal of the season, a one-timer from the left circle, got past Luongo at 5:58 of the third period to put Columbus ahead.
SENATORS 1, MAPLE LEAFS 0
Spezza scored on the power play at 7:35 of the second period as Erik Karlsson found him alone in the faceoff circle and the Senators' captain caught the inside of the post for his 23rd of the season. Spezza now has 56 points in 56 career games against the Leafs.
The Senators tied a season high with their fourth straight win.
James Reimer had 36 saves, making a number of big stops to keep Toronto in the game. The Leafs capped off their season with 12 losses in their last 15 games, leaving them below the Senators in the standings.
SHARKS 3, COYOTES 2
GLENDALE, Ariz. -- Joe Pavelski had two goals to become the fourth player in team history with 40 goals in a season and San Jose closed out the regular season with a win.
Mike Ribeiro and Doan scored for Phoenix, which lost its seventh straight.
PREDATORS 7, BLACKHAWKS 5
The teams combined to score seven goals in a wild and furious final period. Chicago was up 3-2 going into the third, and Nashville finally put the Blackhawks away with the two goals inside the final minute. Nashville had scored more than seven goals only once in franchise history.
Copyright 2014 by The Associated Press
This story is from ESPN.com's automated news wire. Wire index
MORE NHL HEADLINES
- Brodeur retires, to join front office with Blues
- Ducks shut out Canucks, extend streak to 6
- Division-leading Islanders dominate Rangers
- Red Wings edge Panthers for 6th straight win