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Tampa Bay Devil Rays @ Boston Red Sox

Fenway Park (outdoor) 1:05 p.m. ET (30-percent chance of rain, high of 80 degrees, winds up to 20 mph)
Edwin Jackson, RHP (1-8, 6.88 ERA, 1.87 WHIP) versus
Tim Wakefield, RHP (8-8, 4.31 ERA, 1.33 WHIP)

Notable Injuries: Coco Crisp, OF (thumb, day-to-day); Kevin Youkilis, 1B (quadriceps, day-to-day)

Game Story: Though Jackson is coming off back-to-back quality starts, these Red Sox have the lumber to get to him. Remember, he has a 6.49 ERA and 1.86 WHIP in six starts since June 1, so you know what to do on the Boston side. One note: Crisp was expected back Tuesday, so rookie Jacoby Ellsbury will probably be back in Triple-A Pawtucket before this game. In addition, take note of Wakefield's career mastery of the Devil Rays; he's 15-2 with a 2.91 ERA lifetime against them. Carl Crawford (20-for-61, .328, 2 HR) and Jorge Cantu (7-for-21, .333, 1 HR) have good track records against the right-hander, and those are always worth taking into account against a knuckleballer. They're often tough to predict, so go with the guys you know can hit them.

Minnesota Twins @ New York Yankees

Yankee Stadium (outdoor) 1:05 p.m. ET (20-percent chance of rain, high of 80 degrees)
Johan Santana, LHP (9-6, 2.76 ERA, 1.04 WHIP) versus
Mike Mussina, RHP (4-5, 4.63 ERA, 1.32 WHIP)

Notable Injuries: none

Game Story: I've been making a big deal about the Yankees' struggles against left-handed pitching in this column of late -- .267 BA/.734 OPS -- and you can't ask for a tougher lefty than Santana. Keep in mind these Yankees managed a combined three runs in games against Erik Bedard, Jeff Francis, Noah Lowry and Oliver Perez the past three weeks, so in shallow leagues, Bobby Abreu (.245/.616 against lefties), Robinson Cano (.257/.696), Johnny Damon (.273/.699) and even Hideki Matsui (.233/.694) are actually shakier options. Stick with the rest, though, and stick with Mussina, unless wins are your primary objective. He has five consecutive quality starts and a 2.56 ERA in that span, and these Twins aren't exactly an elite offense.

Toronto Blue Jays @ Oakland Athletics

McAfee Coliseum (outdoor) 4:05 p.m. ET (sunny, high of 81 degrees)
Dustin McGowan, RHP (4-4, 5.15 ERA, 1.38 WHIP) versus
Joe Kennedy, LHP (2-6, 3.91 ERA, 1.47 WHIP)

Notable Injuries: Marco Scutaro, IF (hand, day-to-day)

Game Story: The Dustin McGowan you need to get to know is 4-3 with a 4.20 ERA and 1.28 WHIP in his last eight starts. Sounds decent, right? That seems like a good-enough starter who occasionally will disappoint you, which isn't bad to own. In other words, ride the matchups, and this one, at a pitcher-friendly ballpark against the 20th-ranked Athletics offense (4.48 runs per game), is favorable enough to use him. That said, stick with the hot-hand Athletics hitters, like Jack Cust (23-for-59, .390, 6 HR in his last 15 games), Mark Ellis (.330/.931 since June 1) and Shannon Stewart (19-for-38, .500, 3 HR in his last eight games). Avoid Kennedy, though. These Blue Jays torment left-handers (.292/.825 as a team), especially Troy Glaus (.333/1.113), Aaron Hill (.338/.960), Alex Rios (.341/.980) and Frank Thomas (.311/1.005).

Cleveland Indians @ Detroit Tigers

Comerica Park (outdoor) 7:05 p.m. ET (50-percent chance of rain, low of 67 degrees, winds up to 20 mph)
Jake Westbrook, RHP (1-3, 6.10 ERA, 1.45 WHIP) versus
Kenny Rogers, LHP (2-0, 0.75 ERA, 0.58 WHIP)

Notable Injuries: none

Game Story: Rogers always seems to kick off seasons well, doesn't he? He has looked great in each of his first two turns off the DL, and he'll only be closer to 100 percent as time passes, meaning this isn't as scary a matchup as it might seem. Sure, Travis Hafner (9-for-18, .500, 2 HR) owns him, and Victor Martinez (11-for-36, .306) and Jason Michaels (6-for-17, .353) hit him well, but don't dig too deep beyond your Indians regulars. Plus, his opponent, Westbrook, faces an even more treacherous matchup. The Tigers routinely pound the right-hander; he has a 6.71 ERA in 10 career games (nine starts) at Comerica, and this year's Tigers rank first with ease in scoring (5.90 R/G). Brandon Inge (7-for-27, .259, 2 HR), Craig Monroe (10-for-30, .333, 2 HR), Magglio Ordonez (9-for-26, .346, 3 HR) and Marcus Thames (2-for-4, .500, 1 HR) all hit him well.

Baltimore Orioles @ Chicago White Sox

U.S. Cellular Field (outdoor) 7:05 p.m. ET (30-percent chance of rain, low of 67 degrees)
Garrett Olson, LHP (First career MLB start) versus
Jose Contreras, RHP (5-9, 4.89 ERA, 1.47 WHIP)

Notable Injuries: Melvin Mora, 3B (foot, day-to-day); Scott Podsednik, OF (rib cage, DL); Steve Trachsel, SP (gluteus, DL)

Game Story: Olson earned the start in Trachsel's place after winning four consecutive decisions for Triple-A Norfolk; he had a 3.46 ERA, 1.06 WHIP and .211 BAA in 17 starts there for the season. He's well worth a pickup, but as with any rookie, it's anyone's guess how effective he'll be right off the bat. For AL-only owners, this isn't a bad matchup; the White Sox rank 29th in scoring (3.91 R/G) and are anemic against left-handers (.229/.672). Still, Jermaine Dye (.270/.768), Josh Fields (.360/1.189) and Paul Konerko (.282/.909) hit left-handers well enough to keep active. Leave Contreras in there, too. He's effective enough to handle the Orioles, though Jay Gibbons (4-for-9, .444) and Kevin Millar (7-for-13, .538, 2 HR) hit him well.

Seattle Mariners @ Kansas City Royals

Kauffman Stadium (outdoor) 8:10 p.m. ET (40-percent chance of rain, low of 69 degrees)
Jarrod Washburn, LHP (7-6, 4.03 ERA, 1.38 WHIP) versus
Brian Bannister, RHP (5-4, 3.58 ERA, 1.23 WHIP)

Notable Injuries: Richie Sexson, 1B (thumb, day-to-day)

Game Story: The Royals are even less effective against left-handers (.246/.692) than right-handers (.260/.714), perhaps because some of their most intriguing batsmen -- David DeJesus, Alex Gordon and Mark Teahen -- hit from the left side. In other words, Washburn warrants rare spot-start attention in a road assignment; he actually has a win at Kauffman Stadium already this year (May 27: 7 IP, 4 H, 3 ER). DeJesus (5-for-10, .500) does hit him well enough to keep active, though. Avoid Bannister against these gritty Mariners. They've already beaten him twice this season (April 29, May 26), with Adrian Beltre (2-for-6, .333), Yuniesky Betancourt (2-for-6, .333), Raul Ibanez (2-for-5, .400) and Kenji Johjima (2-for-3, .667, 1 HR) giving him the most trouble.

Los Angeles Angels @ Texas Rangers

Rangers Ballpark (outdoor) 8:35 p.m. ET (60-percent chance of rain, low of 72 degrees)
Jered Weaver, RHP (6-4, 3.55 ERA, 1.45 WHIP) versus
Jamey Wright, RHP (1-2, 6.38 ERA, 1.96 WHIP)

Notable Injuries: Erick Aybar, IF (hand, DL); Mike Napoli, C (ankle, DL); Reggie Willits, OF (knee, day-to-day); Jerry Hairston Jr., 2B/OF (knee, day-to-day); Ian Kinsler, 2B (foot, DL)

Game Story: Why should an assignment at hitter-friendly Rangers Ballpark faze Weaver? He has started there twice in his career and thrived each time, with a win, 14 innings pitched, one run allowed and 14 strikeouts. Three of the four Rangers who hit him best -- Hank Blalock, Kinsler and Mark Teixeira -- are on the DL; Michael Young (4-for-13, .308) is the only one active. Wright, meanwhile, does pitch deep into games and doesn't match up well in a home start against the sixth-ranked Angels offense (5.07 R/G). Go heavy on left-handed Angels hitters. In particular, Casey Kotchman (.320/.955 against righties), Gary Matthews Jr. (.299/.816) and Willits (.315/.804) stand out.

Chicago Cubs @ Washington Nationals

RFK Stadium (outdoor) 12:05 p.m. ET (30-percent chance of rain, high of 85 degrees)
Rich Hill, LHP (5-5, 3.49 ERA, 1.10 WHIP) versus
Matt Chico, LHP (3-5, 4.74 ERA, 1.54 WHIP)

Notable Injuries: none

Game Story: Hill is in a mini-slump, with an 8.49 ERA and .320 BAA in his past three starts, but there isn't a much better cure for that kind of thing than an assignment at RFK against the game's weakest offense (3.70 R/G). Don't count on a stellar outing, but expect a solid one, limiting your Nationals choices to the right-handers who have hit him, like Austin Kearns (2-for-5, .400) and Ryan Zimmerman (2-for-3, .667). As for Chico, expect his magic to begin to fade here, against a Cubs offense loaded with right-handed sluggers. Mark DeRosa (.284/.754 against left-handers), Derrek Lee (.340/.983), Aramis Ramirez (.380/1.266) and Alfonso Soriano (.303/.973) should give Chico fits.

San Francisco Giants @ Cincinnati Reds

Great American Ball Park (outdoor) 1:15 p.m. ET (20 percent chance of rain, high of 89 degrees, winds up to 26 mph)
Matt Cain, RHP (2-9, 3.38 ERA, 1.30 WHIP) versus
Bronson Arroyo, RHP (2-9, 4.89 ERA, 1.49 WHIP)

Notable Injuries: none

Game Story: The Reds' decision to keep Arroyo on four days' rest helped him to a standout effort last Friday, but that was against the Cardinals; before that he was getting regularly tattooed when called upon every fifth day. Of course, these Giants are an even worse offense than the Cardinals, ranking 26th (4.24 R/G), so keep Arroyo in there except in the shallowest leagues, and ride mainly the Giants who tear it up at Great American Ball Park: Pedro Feliz (.316/.986), Omar Vizquel (.325/.807) and Randy Winn (.333/1.027). With Cain on the mound, count on a reasonably low-scoring game for this park. He's a strikeout artist, and these Reds do strike out, ranking seventh in MLB with 588. Keep only your usual Reds in the lineup against Cain.

Philadelphia Phillies @ Houston Astros

Minute Maid Park (indoor/retractable roof) 2:05 p.m. ET
Cole Hamels, LHP (9-4, 3.87 ERA, 1.22 WHIP) versus
Chris Sampson, RHP (6-5, 4.15 ERA, 1.31 WHIP)

Notable Injuries: none

Game Story: Hamels should mow through these Astros hitters, as he has so far in his brief career. He won at Minute Maid in his only career start there last Sept. 16 and has held current Astros hitters to a 11-for-58 (.190) combined performance with 16 strikeouts. Plus, the Astros have precious few lefty killers: Craig Biggio (.365/.965), Mark Loretta (.314/.940) and Hunter Pence (.413/1.068), but Biggio is actually 1-for-10 lifetime against Hamels. As for Sampson, while it's nice that he has a 3.56 ERA at home this year, he had his worst start of the season against these Phillies on April 23 (4 IP, 14 H, 7 ER). Jimmy Rollins (3-for-6, .500, 1 HR), Aaron Rowand (2-for-3, .667) and Shane Victorino (2-for-5, .400) should again get the best of the right-hander.

Milwaukee Brewers @ Pittsburgh Pirates

PNC Park (outdoor) 4:05 p.m. ET (50-percent chance of rain, high of 83 degrees)
Claudio Vargas, RHP (6-1, 4.29 ERA, 1.51 WHIP) versus
Ian Snell, RHP (6-5, 2.90 ERA, 1.17 WHIP)

Notable Injuries: J.J. Hardy, SS (stomach virus, day-to-day)

Game Story: Snell has been lights-out in his home games all year, with a 2.26 ERA and 1.13 WHIP in eight starts, and these Brewers do struggle a bit more against right-handers (.258/.764) than left-handers (.289/.853). It'll actually be his first start against them this season, though Prince Fielder (4-for-9, .444, 1 HR) knows him well from their pasts. Go only for those Brewers who hit righties well: Corey Hart (.326/.904) and Geoff Jenkins (.293/.901), in particular. Stick with Vargas in NL-only leagues. He's a serviceable starter who warrants matchup consideration, and a game against the Pirates' 28th-ranked offense (4.09 R/G) isn't a bad one. Jason Bay, though, owns Vargas (6-for-11, .545, 2 HR).

Arizona Diamondbacks @ St. Louis Cardinals

Busch Stadium (outdoor) 7:15 p.m. ET (40-percent chance of rain, low of 74 degrees)
Livan Hernandez, RHP (5-5, 4.58 ERA, 1.61 WHIP) versus
Brad Thompson, RHP (6-3, 4.88 ERA, 1.48 WHIP)

Notable Injuries: none

Game Story: Hernandez threw a seven-inning, three-hit, one-run (unearned) effort at "new" Busch on April 29, 2006, and today's Cardinals are hardly the hitters of that model. As such, the right-hander warrants spot-start consideration, even if these Cardinals get to right-handers (.271/.734) significantly more easily than left-handers (.248/.674). Juan Encarnacion (20-for-52, .385, 3 HR) and Adam Kennedy (3-for-5, .600) do handle Hernandez, though. Thompson, meanwhile, has back-to-back quality starts despite two relief appearances in between, and he'll be facing a Diamondbacks offense ranked 27th (4.17 R/G). He warrants NL-only consideration, but that doesn't mean sit Eric Byrnes (.343/.895 against righties), Orlando Hudson (.299/.849) or Chad Tracy (.298/.944).

New York Mets @ Colorado Rockies

Coors Field (outdoor) 8:05 p.m. ET (20-percent chance of rain, low of 59 degrees)
John Maine, RHP (9-4, 2.74 ERA, 1.15 WHIP) versus
Josh Fogg, RHP (3-6, 5.31 ERA, 1.55 WHIP)

Notable Injuries: none

Game Story: Coors isn't what it used to be, so there's no reason to fear Maine's matchup. He's 6-1 with a 2.24 ERA in eight road starts this year, and included in that are wins at Arizona's Chase Field and Philadelphia's Citizens Bank Park, each similar hitter-friendly ballparks. Plus, Maine already has beaten the Rockies once this year (April 23), with only Todd Helton (2-for-3, .667) and Matt Holliday (3-for-4, .750) really getting to him. The Mets, meanwhile, should have a field day against Fogg. Among Mets that dominate the right-hander: Carlos Beltran (7-for-17, .412), Shawn Green (10-for-28, .357), Paul Lo Duca (7-for-16, .438), Jose Reyes (4-for-11, .364) and Jose Valentin (2-for-7, .286, 1 HR). Since it's at Coors, expect the Mets to rack up the runs.

Florida Marlins @ San Diego Padres

Petco Park (outdoor) 9:05 p.m. ET (cloudy, low of 64 degrees)
Josh Johnson, RHP (0-3, 10.97 ERA, 3.19 WHIP) versus
Chris Young, RHP (8-3, 2.14 ERA, 1.09 WHIP)

Notable Injuries: Armando Benitez, RP (back, day-to-day); Hanley Ramirez, SS (hamstring, day-to-day); Terrmel Sledge, OF (thumb, day-to-day)

Game Story: Johnson hasn't looked close to the pitcher he was in 2006, or close a pitcher at 100-percent health, in any of his three starts since coming off the DL, and while a road assignment at Petco will prove his most favorable matchup yet, he's in for a tough time. Young has a 0.94 ERA and 0.94 WHIP in seven home starts this year, and these Marlins combine for a 6-for-30 performance (.200) with one homer and 15 strikeouts against him. Mike Jacobs (3-for-5, .600, 1 HR) is the only Marlin with a shred of success against Young. Go for Terrmel Sledge (.260/.805 against righties) in NL-only formats, as the Padres shouldn't have much trouble getting to the shaky Johnson.

Atlanta Braves @ Los Angeles Dodgers

Dodger Stadium (outdoor) 9:10 p.m. ET (clear, low of 66 degrees)
Chuck James, LHP (7-7, 4.08 ERA, 1.50 WHIP) versus
Mark Hendrickson, LHP (2-3, 4.08 ERA, 1.30 WHIP)

Notable Injuries: none

Game Story: That the Dodgers are an offense so predominantly left-handed might suggest James has the edge here, but don't be too hasty. Lefties Luis Gonzalez (.328/.944) and James Loney (.583/1.615) have had no problem hitting that side, while Juan Pierre (.217/.461) is the only one playing like he should have a platoon mate. In NL-only leagues, James is talented enough to keep in, but don't avoid your Dodgers, either. Pierre, incidentally, is 3-for-5 (.600) lifetime against James, which is encouraging. Avoid Hendrickson, though. The Braves have enough lefty killers to make him a shaky fantasy option, considering the numbers of Matt Diaz (.346/.857), Chipper Jones (.301/.948), Edgar Renteria (.345/.950) and Jarrod Saltalamacchia (.333/1.006)

Bronson Arroyo, SP, CIN versus San Francisco Giants
Yuniesky Betancourt, SS, SEA @ Kansas City Royals
Jack Cust, DH, OAK versus Toronto Blue Jays
Mark DeRosa, 2B/3B, CHC @ Washington Nationals
Chris Duncan, OF, STL versus Arizona Diamondbacks
Josh Fields, 3B, CHW versus Baltimore Orioles
Shawn Green, OF, NYM @ Colorado Rockies
Livan Hernandez, SP, ARI @ St. Louis Cardinals
Brandon Inge, 3B, DET versus Cleveland Indians
Geoff Jenkins, OF, MIL @ Pittsburgh Pirates
Dustin McGowan, SP, TOR @ Oakland Athletics
Kevin Millar, 1B, BAL @ Chicago White Sox
Shane Victorino, OF, PHI @ Houston Astros
Tim Wakefield, SP, BOS versus Tampa Bay Devil Rays
Jarrod Washburn, SP, SEA @ Kansas City Royals
Reggie Willits, OF, LAA @ Texas Rangers

Please Note that the notable injuries are not meant to be a comprehensive report of each team's disabled list. For brevity, we include only day-to-day injuries or new DL additions for players you might otherwise consider using in these games. Long-term DL or day-to-day injuries to starting pitchers who were not scheduled to appear are omitted.

Tristan H. Cockcroft covers fantasy sports for ESPN.com. You can e-mail him here.