Bryant scored 34 points in 40 minutes, but the Lakers lost 96-94.
Lakers coach Phil Jackson said before Sunday's game that Bryant would likely play despite being a little late to the game because of the illness. Bryant was not in the locker room while it was open to the media.
It was unclear how Bryant contracted the illness, although Jackson speculated that the All-Star likely ate something that didn't sit well.
The Lakers have the best record in the Western Conference, but they have lost three straight for the first time since acquiring All-Star forward Pau Gasol in February 2008.
Information from The Associated Press was used in this report.