Lupul played for the Ducks in Sunday night's 3-0 home loss against Phoenix.
"I was definitely excited. It's been a long time," Lupul said. "I was pretty pumped up. During the anthem and everything, I was ready to go. But once the game started, it was just kind of business as usual. I'm happy to get this first game out of the way. It's been a long road."
Anaheim sent right wing Dan Sexton back to Syracuse of the AHL to clear a roster spot for Lupul.
The right wing hadn't played for the Ducks since Dec. 8, 2009. Lupul underwent surgery on a herniated disk in his back and then developed a serious blood infection that required several months of recovery.
Anaheim reacquired Lupul from Philadelphia in a trade for Chris Pronger in June 2009. He has scored at least 20 goals three times in his six NHL seasons.