Francona said that Wakefield's start was cemented when he didn't have to pitch Wednesday night. Wakefield pitched an inning in Game 1, 3 1/3 innings in Game 3 and three innings in Game 5, earning the win.
Bronson Arroyo will come out of the bullpen.
"Bronson proved his resiliency with his arm, and his effectiveness," Francona said.
Lowe, who pitched six innings and won Wednesday, also started Game 4.
Schilling, with sutures in his ankle to stabilize a tendon injury, won Game 6 after a disappointing loss in Game 1.
Red Sox team physician Dr. Bill Morgan said he will perform the same procedure on Schilling's ailing ankle that allowed Schilling to pitch in Game 3 of the ALCS, Friday at noon at Fenway Park.
Dr. Morgan will use sutures to hold the torn tendon in place to allow him to pitch in the World Series. Schilling, who will have offseason surgery to repair the tendon, ripped one of the sutures in Game 3 on Tuesday night but continued to pitch as blood dripped from his sock.
Martinez pitched the seventh inning Wednesday, in addition to his Game 5 start and Game 2 loss.