Shortstop has migraine headaches
Berroa, the AL Rookie of the Year last season, missed Friday night's 9-7 loss at Minnesota with flulike symptoms.
"We ran some tests, including (a spinal tap) and the doctor recommended we rest him," manager Tony Pena said.
Berroa, who hit .287 with 17 homers and 73 RBIs last year, is hitting .296 (8-for-27) with one homer.
Appier was scheduled to start Saturday for the first time since Aug. 26. During the offseason, Appier had surgery to repair a flexor tendon tear in his right elbow.
Kansas City also purchased the contract of shortstop Andres Blanco from Double-A Wichita and sent left-hander Jaime Cerda to Triple-A Omaha.
Right-hander Miguel Asencio was moved from the 15- to the 60-day DL to make room on the 40-man roster.
Blanco was in the starting lineup against Minnesota, batting ninth, as the Royals tried to snap a four-game losing streak.
The 20-year-old from Carabobo, Venezuela, was hitting .292 over the first eight games with Wichita. He hit .244 with 61 runs and 25 RBIs in 113 games for Class-A Wilmington last year.
Copyright 2004 by The Associated Press
MORE MLB HEADLINES
- Banks died after heart attack, family says
- Sources: A-Rod, Manfred meet to clear air
- Tulo, CarGo healthy, committed to Rockies
- Outgoing Selig dreams of 'international' MLB