Walker missed 68 games
Walker got a hit on his first pitch from Milwaukee's Doug Davis, driving the ball off the fence in left-center field. In the fourth, the first pitch from Davis struck Walker on the arm but he did not appear to be injured. He struck out in the sixth and walked in the eighth.
The Brewers spoiled his return by winning 6-2.
It was the first time this season the Rockies had their projected opening day lineup. Preston Wilson was activated from the disabled list last week.
Walker, 37, is a three-time batting champion, seven-time Gold Glove winner, five-time All-Star and the 1997 NL Most Valuable Player.
Colorado optioned utilityman Kit Pellow to Triple-A Colorado Springs to clear a roster spot.
Copyright 2004 by The Associated Press