Last year's World Series MVP was injured on the first at-bat of the game when he fielded Ivan Rodriguez's grounder and threw him out.
"We put him in a splint, tried to calm [the injury] down" after he landed on it, manager Terry Francona said. "He's pretty tender. ... For him to come out of a game, you know it's hurting."
Sean Casey pinch hit for him in the second and stayed in the game at first base while Kevin Youkilis moved from first to third. Lowell was 6-for-30 with no homers or RBIs in Boston's first eight games.