Pierre left in the sixth inning after hurting his knee sliding into second base on a successful steal. Angels shortstop Erick Aybar fell on Pierre's knee and Pierre writhed in pain for a few moments before limping off the field.
Pierre had an MRI exam in Los Angeles on Monday that revealed a sprained medial collateral ligament. The 30-year-old Pierre's DL stint is his first in nine seasons.
Dodgers manager Joe Torre said Pierre will be out 4-6 weeks.
"It sounds like it was better news than it could've been," Torre said before the Dodgers opened a four-game series in Houston.
Torre talked to Pierre on Monday and said the outfielder could be ready for light exercises by the end of the week. Torre said Pierre was relieved that the injury wasn't more serious.
"I think he was expecting worse than that," Torre said.
The Dodgers recalled Jason Repko from Triple-A Las Vegas, and he replaced Pierre in center field and the leadoff spot for the opener of Los Angeles' four-game series at Houston. Repko went 0-for-5 with four strikeouts in the Dodgers' 4-1 loss.
Repko was hitting .277 with six homers, 29 RBIs and 15 steals in 74 games with Las Vegas.
Torre said he would consider keeping Repko in Pierre's spot for the short term.
"We'll look at him," Torre said. "His ability to drop a bunt, be aggressive, steal a base -- he seems to have the savvy to lead off. He's aggressive, yet he has a few different things he can do."
Pierre is hitting .277 with 35 steals, second in the NL. The Dodgers' regular leadoff man is baseball's active steals leader with 424.
Information from The Associated Press contributed to this report.