With two outs and a man on second, Jacoby Ellsbury hit a sharp grounder to first base. Contreras got a late start to cover the base and couldn't handle Nick Swisher's wide throw. Contreras ran past the bag, then fell to the ground at the end of the infield while trying to avoid Ellsbury.
Contreras writhed in pain on the ground, clutching his ankle. He needed help to walk off the field. D.J. Carrrasco relieved him and got out of the inning with no runs.
Contreras was activated before the game. He had been on the 15-day disabled list with right elbow tendinitis and hadn't started since July 13 at Texas.
The 36-year-old right-hander is 7-6 with a 4.60 ERA. He hasn't earned a decision since picking up a win against the Cubs on June 27 and hasn't beaten an American League team since June 5 against Kansas City.