Meche was placed on the disabled list July 18 with a lower back strain. He was 4-9 with a 4.50 ERA in his first 19 starts of the season.
Kansas City's Opening Day starter is making his first start since July 11.
To make room for Meche, the Royals placed right-hander Doug Waechter on the 15-day disabled list because of a right shoulder strain. Waechter 0-0 with an 8.44 ERA in five appearances for the Royals.