Damon was 0 for 2 when he departed after the fourth inning on a chilly afternoon against the Twins. He was replaced by Ryan Raburn. The team said Damon's status is day to day, and he is not expected to miss much time.
The Tigers have Thursday off before playing Friday at Cleveland, and manager Jim Leyland said he expected Damon to be ready to face the Indians.
"If he needs a blow, he's going to let me know," Leyland said. "He's fine. He had a tough time sleeping last night and then the calf tightened up, so I didn't want to take any chances with it."
Damon is batting .308 with 21 runs and 14 RBIs in his first season with the Tigers. He has started 27 of Detroit's 29 games.
"It's better if I miss six innings now," Damon said. "It's tight, but it's going to be all right."
Damon said he hasn't been sleeping well for the past week.
"I have to lay off the caffeine," he said.