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CHICAGO (AP) -- More than five hours after he stepped in to lead off the game, Shannon Stewart delivered the key hit to finally put it to bed Tuesday night.

Stewart's RBI single in the 16th inning got the Minnesota Twins' offense rolling and they added four more runs to beat the Chicago White Sox 9-4 and send them to their first four-game losing streak of the season.

"It's very tough to keep your concentration as the game keeps going on. I think the advantage is to the pitcher," Stewart said.

"I was just able to get it by [Joe Crede] right over the bag."

The Twins tied the game at 4 in the top of the ninth when Michael Cuddyer homered off Chicago closer Dustin Hermanson, ending his streak of 15 straight saves and saddling him with just his second blown save in 32 chances.

"I was able to sit back on it, had a good swing and drove it over the fence," Cuddyer said.

"One bad pitch," Hermanson said. "It's discouraging. I guess sometimes it's going to happen. But unfortunately it was a big game for us."

The Twins' bullpen allowed five hits in 9 1/3 scoreless innings and their offense finally broke through to end the 5-hour, 9-minute game.

Minnesota finished with 20 hits in the second-longest game in the majors this season. Toronto beat the Los Angeles Angels 2-1 in 18 innings on July 28 in the longest game of the year.

Michael Ryan singled to start the 16th and was forced at second on Cuddyer's bunt back to Jon Adkins, with the White Sox arguing that they turned a double play on the relay to first.

"I thought I made a good play and I thought [Juan] Uribe made a good turn," Adkins said. "I just didn't get the job done."

Adkins (0-1) then walked Brent Abernathy before Stewart, who entered the game in an 0-for-16 slump, singled past third baseman Crede for his third hit of the game. Joe Mauer's RBI double gave the Twins a two-run cushion, Terry Tiffee added a two-run single and Lew Ford another RBI single.

"I don't know to describe this game," Twins manager Ron Gardenhire said.

"It became a game of perseverance. Both bullpens were matching each other inning for inning. We finally got some big hits."

J.C. Romero (3-3) pitched two innings for the win. Joe Nathan, the fifth Twins reliever, pitched the bottom of the 16th, striking out the side.

After his game-tying homer, Cuddyer later made a great stop at third in the bottom of the 11th to rob Crede of a hit with the game-winning run at second.

"He hit a bullet and I was able to make the play on a short hop. A few inches over and it would have been past me," Cuddyer said.

The White Sox threatened in the 13th after A.J. Pierzynski doubled with one out, but after an intentional walk, Jesse Crain retired Uribe and Crede.

Chicago took 4-3 lead in the seventh on Timo Perez's two-out, two-run double off Brad Radke.

Radke took a 3-1 lead into the bottom of the sixth, thanks to Justin Morneau's two-run homer off Chicago starter Freddy Garcia in the top of the inning.

But Carl Everett homered in the bottom half to make it a one-run game, and the White Sox started their seventh inning rally with a rarity -- a walk by Juan Uribe off Radke, who'd allowed just 16 free passes all season.

After Crede flied out for the second out of the inning, Brian Anderson -- in his major-league debut -- fought his way out of an 0-2 hole and reached out and poked a single to left for his big league hit, setting the stage for Perez.

Perez, in a 5-for-37 slump entering the game and hitting leadoff with Scott Podsednik on the disabled list, also doubled and scored in the fourth on a single by Tadahito Iguchi.

Morneau, in a 7-for-40 skid before singling in the fourth, hit his 17th homer to deep right after Joe Mauer led off the sixth with a walk, but Radke couldn't hold the two-run cushion.

Garcia allowed nine hits and three runs in seven innings, improving to 3-4 at home.

Radke retired the first nine batters before Perez's double in the fourth.

Radke gave up seven hits and four runs in 6 2/3 innings. He was allowing an average of less than one walk per game this season and hadn't walked a White Sox batter since 2002 in a span of 12 starts against Chicago.

Stewart doubled leading off the game and scored on Mauer's RBI double.

Game notes

It was the longest game in the history of U.S. Cellular Field which opened in 1991. ... Stewart left the game after his 16th inning hit after straining his groin. ... Anderson started in right field in place of Jermaine Dye, who entered the game in the ninth. ... Minnesota's Matt Guerrier allowed just two hits in four innings of relief and extended his scoreless streak to 18 1/3 innings.