• Wasted effort: In his second game since returning after a treatable form of lymphoma derailed his promising 2006 rookie season, Red Sox starter Jon Lester pitched 6 2/3 innings, allowing four runs on six hits and a walk. Solo homers by Tampa Bay's Jonny Gomes and Josh Paul chased Lester in the seventh, before the Devil Rays completed the comeback to send the game to extras.
• Figure this: Jonathan Papelbon gave up a game-tying homer on Gomes' second shot of the game in the ninth for the closer's second blown save in 25 chances, the other coming May 1 against Oakland.
• Free falling: The Devil Rays have allowed 83 runs during their eight-game losing streak and are 5-25 since June 25.
-- ESPN.com news services
Red Sox 12, Devil Rays 6 (12 innings)
Jonny Gomes spoiled Lester's bid for his second straight win since rejoining the team with a two-run homer in the ninth, Papelbon's second blown save in 25 chances. But Julio Lugo drew his second bases-loaded walk and Kevin Youkilis followed with a three-run double in Boston's big 12th inning.
"This may not have been as good as the first one or what I wanted, but I'm still happy with it," Lester said.
Lester, whose rookie season ended last year when he was diagnosed with lymphoma, gave up four runs and six hits in 6 2/3 innings. The 23-year-old left-hander left the game with a 5-4 lead, after going six innings last Monday to lead the Red Sox to a 6-2 win over the Cleveland Indians.
"There's no sting," Boston manager Terry Francona said. "We set out to win and we did. It wasn't easy. The score won't indicate the struggles."
Mike Lowell had a one-out single in the 12th off Brian Stokes (2-7), who then loaded the bases with consecutive walks to Jason Varitek and Coco Crisp. After Lowell was forced at the plate on Alex Cora's grounder, Lugo walked to put Boston up 7-6. Jae Kuk Ryu replaced Stokes and gave up Youkilis' double to deep right-center and a two-run double to Manny Ramirez.
Kyle Snyder (2-2) threw two scoreless innings for the win.
David Ortiz had a run-scoring single and Ramirez hit a sacrifice fly to put Boston up 5-2 in the seventh.
Gomes and Josh Paul had seventh-inning solo homers off Lester to pull Tampa Bay within 5-4.
"I need to get five, six, seven innings for a quality start," Lester said. "But the pitch to Gomes was a mistake, while the pitch to Paul was just a piece of good hitting. I get both groundballs and flyouts, but as long as I'm getting them out it doesn't matter. "
The Devil Rays have allowed 83 runs during their eight-game losing streak, and are 5-25 since June 25.
"It's pretty much out there now. There's no running from it at this point," Gomes said. "It's right in front of our face every day. It just seems every seventh game we're trying to break a streak of not winning."
Tampa Bay was without All-Star left fielder Carl Crawford and infielder Ty Wigginton. Crawford was hurt diving for a ball Friday and will be a gametime decision Sunday, while Wigginton was traded to Houston for reliever Dan Wheeler earlier in the day.
James Shields gave up three runs and six hits in five innings. The Devil Rays right-hander is 2-6 with one no decision over his last nine starts after starting the season 6-0.
The Red Sox took a 2-0 lead in the second on an RBI single by Varitek and Lugo's two-out bases-loaded walk. J.D. Drew made it 3-0 on a third-inning RBI single.
The announced crowd of 36,048 was the fourth sellout this year and eighth overall at Tropicana Field. A large number were Red Sox fans.
Devil Rays manager Joe Maddon was ejected in the 11th for arguing a check-swing call. ... Ortiz has a 13-game hitting streak. ... Tampa Bay plans to recall SS Ben Zobrist from Durham Sunday to take Wigginton's spot on the roster. ... Papelbon's other blown save came May 1 against Oakland.