Los Angeles began the night with a magic number of six for clinching the AL West. The White Sox maintained their 1½-game lead over Minnesota in the AL Central.
"All these guys know they have to step it up to protect what we are missing," manager Ozzie Guillen said. "They know Quentin is missing, but they swung the bats well."
AL home run leader Quentin will have surgery on his fractured right wrist Monday, an injury he got earlier this week in Cleveland when -- in frustration after fouling off a pitch -- he hit the bat with his right hand. And Crede, who underwent back surgery last season, has been bothered by soreness and could seek a second opinion.
It's possible neither will play the rest of the season as the White Sox try to make the playoffs.
"Everybody knows obviously it was kind of a freak accident," Buehrle said of Quentin's injury. "[If] you are going to sit there and say, `Oh there goes our chances, we're not going to go to the playoffs now,' it isn't going to get you anywhere."
Buehrle (12-11) allowed only three hits with two walks and seven strikeouts to win for the fourth time in his last five decisions.
The White Sox got a fortunate bounce in the first when Konerko's topped roller up the third base line hit the grass in foul territory and unexpectedly angled fair, giving the slow Chicago first baseman an infield single to load the bases with two outs.
Ken Griffey Jr. followed with a two-run single off Dustin Moseley (1-4), who gave up six hits and four runs in 1 1/3 innings.
Moseley got the start in place of Jered Weaver, who cut some fingers in the dugout in Detroit earlier this week and had his next outing pushed back to Monday.
"I think everybody at this time is going to feel some injuries," Angels manager Mike Scioscia said. "We certainly are. The White Sox certainly are. You have to get after it and play baseball. They have a deep offensive lineup.'
Uribe hit his first two-run homer in the second and after A.J. Pierzynski and Jermaine Dye hit back-to-back singles in the same inning, Scioscia had seen enough and yanked Moseley, bringing in Darren Oliver.
Oliver gave up a solo shot to Konerko leading off the third and after a two-out walk to Nick Swisher, Uribe lined his second of the game and seventh of the season into the left-field bullpen.
"I think he's one of the heart-and-soul guys of this team," Buehrle said, describing Uribe, who played well defensively when Crede was on the DL earlier this season. "We were kind of joking around before the game, `Hey do something, Buehrle is pitching.' And he's like `My brother, my brother, I'll pick him up.' He picked me up all right," Buehrle added.
Alexei Ramirez hit a two-run single in the sixth after a strange play featuring a towering popup from Griffey. With runners at first and second and one out, Griffey's popup landed fair just in front of the plate. Even though the Angels threw to third and second hoping to get a double play, the umpires conferred and ruled Griffey out on an infield fly rule, meaning the runners had to be tagged.
Left fielder DeWayne Wise, who came off the White Sox's disabled list Friday, mishandled Chone Figgins' single in the seventh for an error, allowing the Angels' first run to score. Garret Anderson then followed with an RBI single before Dye made a great diving catch in right center to rob Mark Teixeira of extra bases.
"We were on the brink of getting back into the game," Scioscia said. "And he kind of ended that rally."
It was Uribe's seventh multihomer game. His most recent came Sept. 11, 2007, vs. the Indians. ... Angels 2B Howie Kendrick (strained left hamstring) and SS Erick Aybar (tight left hamstring) are both scheduled to take batting practice on Saturday and run the bases on Monday. ... White Sox reliever Scott Linebrink, who came off the DL four days ago, made his first appearance since July 22. He'd been sidelined by a sore shoulder.