But for the second straight day the Cubs put together a four-run rally in the eighth inning that cut the lead to one.
Suddenly, Wood was in the game, back on the mound, pitching against the Cubs. He wound up getting an ovation -- then blowing the save.
"It wasn't nearly as bad as I thought it would be, as far as adrenaline and being able to control that," said Wood, who spent a decade with the Cubs and saved 34 games for them a year ago before signing with the Indians as a free agent.
What he couldn't control was the hot bat of Lee, whose ninth inning homer was his second of the game and third in two games.
"I felt like he probably had an idea I was going to try and come in. I think he knew what I was trying to do," Wood said after his third blown save in 11 chances.
"It was fun playing with Woody for so long and then playing against him," Lee said. "He is throwing 96, he made a good pitch. He jammed me, it got up in the wind and got out of here."
Wood had even visited the Cubs' clubhouse before the game to say hello to some old friends.
"I heard he was in the weight room. I ran in there to see him and I missed him, so hopefully I get a chance to see him tomorrow," Lee said matter-of-factly. "He might be a little mad at me."
Alfonso Soriano, who hit a game-winning single in the ninth Thursday to beat the Chicago White Sox, drew a two-out walk in the 10th from Luis Vizcaino (1-3) and stole second. Theriot followed with a grounder that took a crazy bounce past first baseman Victor Martinez.
"It worked out, the baseball gods were smiling on me," said Theriot after the Cubs' third win of the week in their final at-bat.
The Indians loaded the bases off Kevin Gregg (2-1) in the top of 10th before Kosuke Fukudome made a nice catch of pinch-hitter Ryan Garko's liner to center field. The Cubs beat Vizcaino, whom they released earlier this season.
Homers by Reed Johnson in the fifth and Derrek Lee in the sixth cut it to 7-2.
Facing reliever Rafael Perez, pinch-hitter Koyie Hill hit a hard grounder that went off third baseman Jhonny Peralta for an error, cutting it to 7-5. Soriano then delivered an RBI single that made it a one-run game.
Former Cubs player Mark DeRosa also made his return to Wrigley. He got a standing ovation in his first at-bat and went 1 for 3 with two walks and an RBI.
"I enjoyed every minute of it until Ryan Theriot's base hit," DeRosa said. "It's good to be back."
DeRosa played left field and was shaken up in the third inning chasing a foul fly by pitcher Rich Harden. As DeRosa reached for the ball in the Cubs' bullpen along the left-field line, he hit the brick wall with his leg and came down on a telephone box, knocking the door open and exposing the phone.
DeRosa limped, bent over at the hip and then after meeting with a trainer, stayed in the game. In the top of the fourth, he delivered a two-out single to put Cleveland up 7-0.
After walks to Jamey Carroll and DeRosa to start the third, Martinez sent his 100th major league homer into the right-field bleachers to make it 6-0 off Cubs' starter Harden.
Valbuena hit his second homer of the season following a triple by Peralta, whose high drive to center went off normally sure-handed Johnson's glove, and a walk to Kelly Shoppach.
Lee has a 16-game hitting streak. ... The start of the game was delayed one hour, 26 minutes by rain.