Price allowed four hits in eight dominant innings and the Tampa Bay Rays beat the slumping White Sox 5-0 on Monday night.
"Price was outstanding," Chicago manager Ozzie Guillen said. "They played defense behind him very well. When you're pitching that way and you make plays behind him, it's hard to beat them."
Price (2-2) struck out nine and walked two. The left-hander entered 0-4 with a 4.88 ERA in four starts against the White Sox.
"It was a big game for me. ... The White Sox have had my number ever since I've been in the big leagues," Price said. "A very tough team to pitch against, and they've got a lot of right-handed hitters that put the bat on the ball. It's tough and it's fun."
Edwin Jackson (2-1) gave up four runs and 11 hits in seven innings for the White Sox, who have lost five in a row. Jackson, while with Arizona, walked eight during a 149-pitch no-hitter against Tampa Bay at Tropicana Field last June 25.
Joel Peralta pitched the ninth to complete the four-hitter.
"We know we're going to hit," Guillen said. "I don't worry about that."
Any chance of a repeat performance by Jackson ended when leadoff hitter Sam Fuld singled to start the Rays' three-run first.
After Lopez drove in Fuld with a single, Zobrist made it 3-0 on his two-run shot. Zobrist had just one hit in 13 at-bats over his previous five games.
Fuld had four hits and made a diving catch in center field during the third to take away a hit from Brent Morel. Rays shortstop Reid Brignac threw out Ramon Castro at first after making a diving stop on a second-inning grounder.
"Couldn't have done it without all the defensive plays," Price said.
Jackson worked out of a two-on, two-out jam in the second by striking out Elliot Johnson. The right-hander, who pitched for the Rays from 2006-08, had won all three previous starts against his former team, including a 5-1 victory over Price on April 7 in Chicago.
"Jackson threw the ball pretty good," Guillen said. "We just didn't score any runs."
Tampa Bay went up 4-0 on Lopez's fifth-inning double. Lopez also had a solo homer off Matt Thornton in the eighth.
Chicago RHP Jake Peavy (right shoulder) lasted just two-thirds of an inning in a rehab start with Double-A Birmingham. The White Sox said he left with discomfort -- where it was located was not disclosed -- and will be evaluated Tuesday. Peavy allowed three runs and four hits. ... Rays All-Star 3B Evan Longoria (strained left oblique) could start a minor league rehab assignment next week and return to the lineup during a series against the Los Angeles Angels that begins April 29. ... White Sox DH Adam Dunn, in a 2-for-23 slide, was not in the lineup against the left-handed Price. ... Chicago LHP Chris Sale, who grew up in nearby Lakeland, attended Tampa Bay's first game on March 31, 1998, when he was 9.