ATLANTA -- Chipper Jones says extra innings "stink" so he was anxious to make sure a game already 4 hours long didn't continue.
"It's always good to come through on your last at-bat," said Jones, who was 0 for 4 with a walk before the game-winning hit.
"One finally fell in, so it was nice," he said.
It was the second extra-inning game in four days for the Reds, who lost 5-4 in 19 innings in Philadelphia on Wednesday night.
The switch-hitting Jones, batting from the left side against the right-handed Fisher, pulled a pitch past second baseman Brandon Phillips into right field. The speedy Schafer easily beat Jay Bruce's throw to the plate.
The teams used 13 pitchers and combined for 30 hits in the game which lasted 4 hours, 3 minutes.
The Braves played their seventh extra-innings game of May, each lasting at least 11 innings, and their fifth in the last 10 games.
Atlanta relievers gave up one run in 8 2/3 innings.
"The bullpen was outstanding," said Braves manager Fredi Gonzalez. "To cover that, wow! Outstanding job."
Scott Linebrink (1-1) pitched two scoreless innings after also pitching two scoreless innings on Friday night. He gave up a hit and issued an intentional walk in the 12th before ending the inning on Drew Stubbs' double-play grounder.
Gonzalez said Linebrink and Jonny Venters, who also threw two scoreless innings, would not be available on Sunday night's final game of the series. Gonzalez said the team may make call up a fresh arm for the game.
The Reds also could make another roster move on Sunday.
"Fisher didn't deserve to lose that one but he was weary, too," said Reds manager Dusty Baker. "We're beat up right now. That 19-inning game, you're still seeing the effects of that."
Stubbs had three hits and drove in three runs and Jonny Gomes had four hits for Cincinnati.
Cincinnati's Arroyo and Atlanta's Lowe, teammates on the Boston Red Sox in 2003-04, had similarly poor starts.
Arroyo gave up nine hits -- including third-inning homers by McCann and Freeman -- and five runs. He has given up 18 runs in 12 2/3 innings over his last three starts.
Arroyo was making his first start since an MRI showed a minor muscle strain in his back.
Lowe left the bases loaded in the first and third innings, retiring Bruce on infield grounders to end each Cincinnati threat.
Lowe's luck ran out in the fourth, when the right-hander blew a 5-0 lead. Stubbs had a three-run double over the head of right fielder Eric Hinske, followed by a run-scoring double by Phillips. Joey Votto's single to center drove in Phillips to tie the game.
Lowe, who walked five for the second straight start, gave up seven hits and five runs in 3 1/3 innings.
"It was frustrating," Lowe said. "It got to the point you were just trying to throw strikes. That's never a good sign.
"You can't act like 10 walks (in two games) isn't a big issue, because it is," Lowe added. "You really have to try to figure it out."
Left-hander Jeremy Horst, called up from Triple-A Louisville earlier in the day, had to wait only a few hours for his major league debut. Horst retired the Braves in order in the fourth and had a run-scoring single in his first at-bat in the fifth. He had four strikeouts in 2 2/3 innings and gave up only one run, McCann's second homer.
Schafer had Atlanta's top defensive play in the seventh when he made a running basket catch at the wall in left-center field to rob pinch-hitter Fred Lewis.
The Reds wasted a scoring chance in the eighth when Scott Rolen's single to left field off Venters moved Votto to third base, but Rolen was thrown out at second base by left fielder Martin Prado.
RHP Daryl Thompson, who gave up five runs in three innings in his only appearance with Cincinnati, was optioned to Double-A Carolina. ... McCann had his seventh career two-homer game while matching his high with four hits. ... Gomes raised his batting average from .168 to .191.