Sellers was promoted from Triple-A Albuquerque when rookie Dee Gordon went on the disabled list on Friday. The 25-year-old shortstop is from nearby Bellflower and made frequent visits to Dodger Stadium with his parents when he was a child.
"It was very special, exciting and emotional for me, my family and my friends who have been there supporting me ever since day one," said Sellers, whose father Jeff spent four seasons in the big leagues as a pitcher for the Boston Red Sox.
Sellers chased rookie Jordan Lyles with a drive into the lower seats in the left-field corner for his first three RBIs in the majors. The sixth-inning homer came in Sellers' ninth big league at-bat.
"My first reaction was: 'I knew I got it.' Running around the bases was just the most incredible feeling I've ever had," said Sellers, whose favorite Dodgers growing up were sluggers Eric Karros, Mike Piazza, Darryl Strawberry and Eric Davis. "It was awesome to have my family here and get it. When I got to the dugout I got a lot of high-fives and hugs and stuff. I've got chills right now talking about it."
Sellers' teammates were certainly pumped -- particularly catcher Dioner Navarro, who surprised him with a shaving cream pie in the face while he was doing a postgame TV interview on the field.
"All home runs are exciting, but you never really forget your first one," said Matt Kemp, one of several players who urged Sellers to acknowledge the curtain call he received from the crowd of 36,339. "That's a good feeling. I know what it felt like to get my first home run. He's from this area and had his family here, so it was a special moment. I'm happy for him. Hopefully, there's more to come."
Kemp matched his career high with his 28th homer for the Dodgers, who had lost four in a row before the lowly Astros came to Chavez Ravine. Navarro also went deep and scored twice.
Kuroda (8-14) allowed five singles, struck out six and walked one. The 36-year-old right-hander, who came in tied with recently demoted Astros left-hander J.A. Happ for the most losses in the NL, won for only the third time in his last 15 starts despite a season ERA of just 2.88.
Kuroda's last five victories have come in games in which he didn't allow a run, dating to his 2-0 win at Pittsburgh on May 11.
"I'm not really used to having this many runs. I'd much rather have it than not have it, but my approach to pitching isn't any different," Kuroda said through a translator. "I'm a starting pitcher, and I want to keep the game close. So the less home runs I give up the better, but it's not because of a lack of run support."
Houston's 38-83 record is the worst in the majors. The Astros trail NL Central-leading Milwaukee by a whopping 32 games -- their largest deficit since ending the 1975 season a franchise-record 43½ games off the pace.
Lyles (1-7) gave up seven runs and seven hits in 5 1-3 innings, including all three home runs. The right-hander, who at age 20 is the youngest player in the majors, has a 5.31 ERA in 13 starts since beating the Chicago Cubs in his big league debut on May 31 at Wrigley Field.
"I just made mistakes throughout the entire game and they made me pay," Lyles said. "On Sellers' home run, I was trying to punch him out with runners on first and second and then just hung a mistake over the plate."
Navarro hit a two-run shot in the second inning for his fifth homer and Kemp made it 3-0 in the third with his second homer in two days after a season-worst 11-game drought.
Dodgers first baseman James Loney pulled off a slick unassisted double play to end the fourth inning, making a leaping grab of Carlos Lee's line drive and spinning around to tag J.D. Martinez as he dove back to the bag.
: Four of Navarro's five homers this season have come in day games, one of them against Astros RHP Wilton Lopez in the eighth inning of a 1-0 victory on June 19 at Los Angeles. Kuroda also started that game and ended up with a no-decision after allowing just three hits in seven innings. ... Pitching at Dodger Stadium for the first time, Lyles walked his first two batters of the game -- equaling the number he had in 32 1-3 innings over his previous five starts. ... The Dodgers' only other three-game sweep this season came against San Diego at Chavez Ravine in the final series before the All-Star break. The Padres and Astros, both last in their respective divisions, are a combined 92-151 and 46½ games out of first place. ... The Dodgers begin 10-game road trip through Milwaukee, Colorado and St. Louis on Monday night. 2B Jamey Carroll is batting a major league-best .344 on the road, compared to .253 at home.