| Wednesday, May 14, 2008 |
| TEAM |
 | Placed pitcher Clay Buchholz on the 15-day disabled list; recalled outfielder Jonathan Van Every from Pawtucket of the International League (AAA). |
 | Placed shortstop Jeff Keppinger on the 15-day disabled list; recalled infielder Paul Janish from Louisville of the International League (AAA). |
 | Activated pitcher Al Reyes from the 15-day disabled list; designated pitcher Scott Dohmann for assignment. Signed pitcher Scott Kazmir to a four-year extension. |
 | Activated outfielder Marlon Byrd from the 15-day disabled list; optioned infielder Travis Metcalf to Oklahoma of the Pacific Coast League (AAA). |
| Tuesday, May 13, 2008 |
| TEAM |
 | Recalled pitcher Jose Arredondo from Salt Lake of the Pacific Coast League (AAA); recalled infielder Maicer Izturis from the 15-day disabled list; optioned pitchers Nick Adenhart and Darren O'Day to Salt Lake. |
 | Placed shortstop Rafael Furcal on the 15-day disabled list, retroactive to May 6; purchased the contract of infielder Luis Maza from Las Vegas of the Pacific Coast League (AAA); transferred infielder Tony Abreu to the 60-day disabled list. |
 | Activated pitcher Matt Wise from the 15-day disabled list; purchased the contracts of pitcher Claudio Vargas and infielder-outfielder Fernando Tatis; placed outfielder Angel Pagan on the 15-day disabled list; designated pitchers Jorge Sosa and Nelson Figueroa for assignment; announced catcher Raul Casanova cleared waivers and assigned him to New Orleans of the Pacific Coast League (AAA). |
| Monday, May 12, 2008 |
| TEAM |
 | Agreed to terms with WLEE 990 AM of Richmond, Virginia on a broadcasting contract. |
| Activated first baseman Sean Casey from the 15-day disabled list; designated pitcher Julian Tavarez for assignment. |
 | Optioned pitcher John Van Benschoten to Indianapolis of the International League (AAA). |
 | Purchased the contract of infielder Edgar Gonzalez from Portland of the Pacific Coast League (AAA); designated infielder Callix Crabbe for assignment. |
| Activated infielder Ben Zobrist from the 15-day disabled list; designated infielder Andy Cannizaro for assignment. |
| Sunday, May 11, 2008 |
| TEAM |
| Purchased the contract of infielder Alex Cintron from Norfolk of the International League (AAA); optioned pitcher Bob McCrory to Norfolk. |
 | Purchased the contract of outfielder Jason Tyner; optioned pitcher Tom Mastny to Buffalo of the International League (AAA). |
 | Activated pitcher Rich Harden from the 15-day disabled list; placed outfielder Chris Denorfia on the 15-day disabled list, retroactive to May 7. |
| Acquired pitcher Bryan Corey from the Boston Red Sox for a player to be named later or cash considerations; optioned pitcher Joe Thatcher to Portland of the Pacific Coast League (AAA). |
| Placed pitcher Kevin Millwood on the 15-day disabled list; purchased the contract of pitcher Doug Mathis from Oklahoma of the Pacific Coast League (AAA). |
 | Recalled pitcher Chris Schoder from Columbus of the International League (AAA); optioned pitcher Mike O'Connor to Columbus. |
| Saturday, May 10, 2008 |
| TEAM |
 | Placed infielder Nick Punto on the 15-day disabled list. |
| Activated outfielder Travis Buck from the 15-day disabled list and optioned him to Sacramento of the Pacific Coast League (AAA). |
| Sent outright pitcher Glendon Rusch to Portland of the Pacific Coast League (AAA). |
 | Activated shortstop Omar Vizquel from the 15-day disabled list. |
 | Placed outfielder Vernon Wells and pitcher Jeremy Accardo on 15-day disabled list; purchased the contract of pitcher Armando Benitez and recalled infielder Joe Inglett from Syracuse of the International League (AAA); designated pitcher Tracy Thorpe for assignment. |
| Friday, May 9, 2008 |
| TEAM |
 | Activated pitcher Scott Eyre from the 15-day disabled list; optioned pitcher Sean Marshall to Iowa of the Pacific Coast League (AAA). |
| Placed pitcher Kent Mercker on the 15-day disabled list, retroactive to May 6; recalled pitcher Bill Bray from Louisville of the International League (AAA). |
 | Sent outright pitcher Derrick Turnbow to Nashville of the Pacific Coast League (AAA). |
| Activated catcher Ramon Castro from the 15-day disabled list; designated catcher Raul Casanova for assignment. |
| Activated pitcher Keith Foulke from the 15-day disabled list. |
| Released outfielder Jim Edmonds; recalled outfielder Jody Gerut from Portland of the Pacific Coast League (AAA); claimed pitcher Sean Henn off waivers from the New York Yankees; purchased the contract of catcher Luke Carlin from Portland; optioned catcher Colt Morton to San Antonio of the Texas League (AA). |
| Acquired outfielder Kevin Mench from the Texas Rangers for cash considerations; signed outfielder Brad Wilkerson; optioned infielder Joe Inglett to Syracuse of the International League (AAA); designated pitcher Gustavo Chacin and infielder Sergio Santos for assignment. |
| Placed catchers Paul Lo Duca and Johnny Estrada on the 15-day disabled list; recalled catcher Jesus Flores from Columbus of the International League (AAA); activated outfielder Elijah Dukes from the 15-day disabled list. |
| Thursday, May 8, 2008 |
| TEAM |
| Activated infielder-outfielder Freddie Bynum from the 15-day disabled list; optioned infielder Eider Torres to Norfolk of the International League (AAA). |
| Named Regis Bane director of ticket operations. |
| Optioned pitcher Dallas Braden to Sacramento of the Pacific Coast League (AAA). |
| Placed pitcher Kevin Cameron on the 15-day disabled list; purchased the contract of pitcher Shawn Estes from Portland of the Pacific Coast League (AAA). |
| Activated pitcher Kason Gabbard and infielder Travis Metcalf from the 15-day disabled list; designated first baseman Ben Broussard for assignment; optioned pitcher A.J. Murray to Oklahoma of the Pacific Coast League (AAA). |
