West, New Orleans' leading scorer and rebounder last season, had scored 17 points for the second straight game before spraining his right ankle and limping to the locker room with 6:07 left in the third quarter. He had played 19 minutes.
Last season, West sprained his left ankle in a preseason game and was hampered by it all season. He still finished second in voting for the NBA's most improved player after averaging 17.1 points and 7.4 rebounds.
Chandler, picked up in an offseason trade with Chicago, left 46 seconds into the second half after spraining his left ankle.
The Hornets were already without free-agent signee Peja Stojakovic because of a left quadriceps strain.