A Trail Blazers spokesman said Oden suffered a midfoot sprain. X-rays were inconclusive. He will return to Portland for an MRI exam on Wednesday. The injury occurred with 9:20 remaining in the first quarter, but Oden continued to play in the first half.
"I hope it's not serious because he's worked so hard to get himself back," Portland coach Nate McMillan said. "We've tried to do all we could to get him into the season, and here we are -- the first game. Hopefully in a couple of days, he can be back."
Oden, the No. 1 overall pick in the 2007 draft, had microfracture surgery on his right knee in September 2007 and missed all of last season. As of Tuesday night, exactly one year and four months after he was drafted, he has yet to score his first NBA point. He missed four field goals and two free throws in 13 minutes of play.
Explaining how he got hurt Tuesday, he said: "I was trying to go get a rebound and kind of came down on Derek Fisher's foot on like the third play of the game. I kind of fell and didn't think twice about it. I tried to play the rest of the half with it.
"I wanted to play in the second half. I was taped. I was trying to run. It just wasn't happening. I'm just trying to get through it and trying to get back. It's just a little setback. I'll still be in the gym tomorrow."
Information from ESPN.com NBA columnist J.A. Adande and The Associated Press was used in this report.