Ginobili has a bruised hip, and coach Gregg Popovich said he decided to give Duncan and Parker the night off in Denver following the Spurs' 110-105 overtime win at Golden State Monday night.
"Ginobili has a left hip contusion among other bumps and bruises. For a different variety of reasons, I don't think Timmy and Tony should play tonight," Popovich said before tip-off.
The Spurs are in the midst of an eight-game road trip. They won't play at home again until facing Dallas on Feb. 24.
Denver's Kenyon Martin also missed the game with tonsillitis and strep throat. He's day to day.