The Timberwolves say Jefferson left the team to be with an ill family member in Florida. He will miss the game Friday night against the Dallas Mavericks and on Saturday at Memphis.
Jefferson is expected to rejoin the team early next week. It's a big blow to the Timberwolves, who have lost eight straight games since a season-opening win over the New Jersey Nets.
Jefferson is averaging 15.1 points and 6.1 rebounds this season. He is still not 100 percent from February surgery on his right knee, but the Wolves will sorely miss his presence in the middle.