Williams got tangled up with Mo Williams and ran over the Cavaliers' point guard, drawing his fifth foul with 11:23 left in the game. Deron Williams started to push himself up, then winced in pain while grabbing at his wrist.
He was led to the locker room while holding his wrist, the same one he sprained and bruised in a fall Jan. 4 against New Orleans, and never returned. Williams had previously missed two games with the injury.
The Jazz also lost forward Andrei Kirilenko in the third quarter Thursday with a hyper-extended right knee.
Information from the Associated Press was used in this report