They'll look to help lead Oklahoma City to a season-best sixth consecutive win Tuesday night against the Brooklyn Nets, who begin a four-game homestand.
The Thunder (14-4) began their streak with a 116-109 overtime win at Philadelphia on Nov. 24 and have won their last four by an average of 25.0 points.
Durant scored 20 points while Westbrook added 18 and 10 assists before both sat out the fourth quarter of a 100-79 rout of New Orleans on Saturday.
"As a team we're doing a better job of not focusing on who we're playing, but focusing on ourselves and trying to find a way where we can get better," Westbrook said.
Durant has a pair of 37-point performances while shooting 56.4 percent during the winning streak, with Westbrook averaging 19.4 points and 9.4 assists.
"Russell was Russell. He was able to get me open shots and I just tried to do my part," Durant said Saturday. "He sets the tone for us by pressuring the point and disrupted them early on."
Westbrook also added three steals, one night after having a season-high seven in a 106-94 win over Utah.
"I thought he had one of his better games," coach Scott Brooks said. "He's had a bunch of them lately on both ends of the floor. There's not a lot of guys in this league that can impact a game defensively and offensively like he has."
Westbrook scored 21 points and Durant added 20 in an 84-74 victory over the Nets on Jan. 21, Oklahoma City's sixth straight in the series.
Brooklyn (11-5) will look to halt that skid in the first of four straight home games against solid competition. It will face Golden State on Friday and Milwaukee on Sunday before another showdown with New York on Dec. 11.
The Nets had their five-game winning streak snapped with a 102-89 loss at Miami on Saturday despite seven players scoring in double figures. Andray Blatche started in place of Brook Lopez (foot) and scored 20 points and grabbed eight rebounds.
Lopez will miss his third straight game Tuesday giving Blatche another start, and coach Avery Johnson hopes he can add a better defensive presence down low.
"One thing from Blatche, and he'll probably tell you the same thing, we need more blocked shots," Johnson said. "We need better defense in the paint. When you move into a starting role, you're playing against a different caliber (of opponent) and things are a lot more magnified. He's capable of it."
The Nets also will be without reserve forward Reggie Evans, averaging a team-high 8.4 rebounds, due to the flu.
Deron Williams, averaging 24.0 points in his last six versus the Thunder, went 3 for 11 from the field and scored 10 against the Heat. He shot 5 of 18 in last season's meeting with Oklahoma City.
Williams has totaled only 29 points over his last three games and is shooting 32.8 percent over his past 10, but the Nets are 7-3 in that span.
"In Deron's case, he'll be fine," Johnson said. "He's the last guy I'm worried about."
Durant has averaged 29.8 points in his last four games against the Nets.