The Timberwolves (3-1) made just five of 20 shots (25 percent) in the opening quarter but ended up with six players in double figures.
Timberwolves guard Sebastian Telfair, who will begin serving a three-game suspension later this month, scored seven points in nearly 20 minutes of play.
Telfair pleaded guilty last month to possession of a handgun in an April 2007 incident and was sentenced to three years' probation. The NBA announced his suspension Tuesday. It is set to begin with the Oct. 29 regular-season opener at home against Sacramento.
The Bulls (0-3) pulled within two points with about three minutes to play on forward Andres Nocioni's 3-pointer, but managed just one field goal the rest of the way as Minnesota closed with an 11-2 run.
Chicago set a brisk early pace, including 11 straight points late in the opening quarter as it opened a 30-13 lead. But the Bulls shot just 5-of-15 from the field in the second quarter and the Timberwolves used a 23-5 surge over the final 7:07 to take a 46-45 halftime lead.
The Bulls led for more than six minutes in the third quarter, but fell behind for good on Randy Foye's 19-foot jumper at the 4:57 mark.