Jordan Farmar came off the bench and scored 15 of his 17 points in the final quarter as Los Angeles (3-2) kept Charlotte (0-7) winless.
The extent of Bryant's injury is not known. The Lakers said that last season's NBA Most Valuable Player will be re-examined on Wednesday.
Bryant was injured with 3:08 left in the second quarter under the Lakers' basket when he jumped for a rebound. Bryant motioned to the bench to come out and coach Phil Jackson called a 20-second timeout as Bryant limped off the floor.
Bryant scored four points in 14 minutes and came out in street clothes for the third quarter.