"With Deron out, we knew we had to step it up," Boozer said. "You've really got to tip your hat to the rookies."
Williams -- who leads the Jazz in scoring and assists -- temporarily left the team to deal with a family medical issue, but could return in time for Saturday's game at Cleveland.
After Friday's game, Williams released a statement which read in part, "We [he and his wife] both appreciate the support of the fans, the Jazz organization and my teammates. I will return to the court as soon as possible."
"From the second quarter on, they pushed us and we didn't push back hard enough," Brand said.
The Jazz held a 23-point lead late in the third quarter when Kirilenko hit a pair of free throws with 22 seconds left to go ahead 92-69. Utah scored the final eight points of the quarter. Utah's lead increased to 26 early in the fourth.
"Maybe if the bully pushes us long enough, maybe we'll push back," Philadelphia coach Eddie Jordan said. "That time hasn't come yet."
The Sixers briefly closed within 99-85 on a jumper by Kapono with 5:41 left before the Jazz pulled away and sealed the win.
Using a 17-4 run late in the second quarter, the Jazz raced to a 60-46 advantage. They led 64-50 at halftime and shot 54 percent from the field.
Iguodala had one free throw attempt in the previous two games. He was 3 for 5 against the Jazz. Utah hit its first 17 free throws before missing. The Jazz had only three turnovers at halftime.