"It's big to see fans with the Oklahoma City jerseys on," Durant said. "I don't care if it's my jersey. I care about Oklahoma City jerseys. I know a lot of the jerseys were for me because I had a lot of family here. It was extra special to get a win here."
Nenad Krstic added 14 points and Russell Westbrook had 10 points and 14 assists for the Thunder (45-28), who swept the season series from Philadelphia for the first time since 1998-99.
"We start every game with the same approach, to have a serious competitive effort no matter who we're playing," Thunder coach Scott Brooks said.
James Harden had 12 points and Serge Ibaka 10 for Oklahoma City, which is nearing its first playoff appearance since 2004-05 as the Seattle SuperSonics.
As usual, Durant provided the big plays for the Thunder.
Durant, the league's second-leading scorer (29.6) behind only LeBron James' 29.8, sparked the Thunder with six points in the final 2:07 of the third quarter. After the Sixers got within 77-70, Durant drove by three Philadelphia defenders and threw down a one-handed dunk.
Durant, who has 22 double-doubles this season, then added a tough runner in the lane and two free throws with 0.9 seconds remaining.
Oklahoma City also received balanced scoring and extended its lead early in the fourth.
The Thunder went on a 17-4 run to open the quarter with reserves scoring all the points. Eric Maynor had six and Harden five as the Thunder increased their lead to 101-78 with 5:55 left.
"Our bench did a great job, especially in the fourth quarter," Brooks said. "Eric Maynor set the tone with a big 3-point shot."
Oklahoma City shot 41 percent from the field but committed only four turnovers in the first half. As a result, the Thunder held a 56-45 advantage at halftime.
The Sixers played without guard Lou Williams (sore lower back) and forward Thaddeus Young (right thumb fracture). ... Philadelphia University men's basketball coach Herb Magee was honored at halftime. Magee recently earned his 903rd career victory, passing Bobby Knight for the most wins in NCAA history. ... There was about a 10-minute delay before the start of the fourth quarter because of a loose wire on the shot clock above one of the baskets.