The 6-foot-11 Villanueva made three 3-pointers, then added a conventional three-point play that started a 10-0 run that put Detroit ahead 60-49 shortly before halftime. The 6-foot-9 Prince then added 10 points in the third quarter and the 6-foot-11 Daye scored seven in the fourth as the Wizards struggled to match up.
"I just tried to come off the bench and provide the team with a spark," Villanueva said. "My teammates did a great job of finding me and were moving the ball great."
Prince, who has been bothered by back problems, finished with 20 points in his first appearance in five games.
John Wall had 24 points and seven assists for the Wizards, who dropped to 1-29 on the road. Detroit has won eight straight over Washington.
The Wizards (16-46) went on a 13-5 run early in the fourth quarter, cutting Detroit's lead to three with 6:55 remaining, but Washington lost track of Greg Monroe near the basket, and the rookie's three-point play made it 92-86.
Wizards coach Flip Saunders missed the game, as expected, two days after the death of his mother. Randy Wittman ran the team in his place.
"We didn't get any stops down the stretch tonight is what it boiled down to," Wittman said. "They hurt us with Tayshaun and [Rodney] Stuckey pick-and-roll and kind of hurt us every which way. Daye hit some 3s, they got some offensive rebounds and overall down the stretch you have to get some stops and we didn't tonight."
Washington was without forward Rashard Lewis, who was out with a sore right knee, and forward Josh Howard, who missed the game because of a strained left hamstring.
Villanueva has been content to stay on the perimeter for much of the season. He has made a career-high 105 shots from 3-point range and is shooting 38 percent from long distance. Daye, in his second season, is shooting 42 percent on 3-pointers. He made two Sunday, including one with 2:16 to play that made it 105-94.
Prince scored six of Detroit's points in a row toward the end of the third, the last two on a 16-footer that made it 80-71.
"I felt slow in the first quarter, because it was tough to get loose, but it felt better the second time I went into the game," Prince said. "The biggest problem I've had is being able to push off with the hip, but there wasn't any pain tonight. I had some stiffness, but I'll get that treated so I'm not too sore in the morning."
Stuckey had 19 points and nine assists for the Pistons (23-41), who went 12 of 18 in the fourth quarter and shot 52 percent for the game.
"I thought we made a conscious effort in our driving and kicking, and guys were sharing the basketball and were very unselfish," Detroit coach John Kuester said.
"I had a lot of people in the crowd and I just wanted to play," Crawford said. "I'm here in Washington and I'm glad to be given the opportunity to play here, and I want to be here for a while."
Detroit lost to Minnesota on Wednesday night for the Timberwolves' fifth road win of the season, but the Pistons were able to prevent the Wizards from earning a rare victory away from home. Washington beat Minnesota at home Saturday night, but the Wizards have won back-to-back games only once all season.
Seven Pistons finished in double figures. Monroe and Daye scored 12 points apiece, and Ben Gordon and Richard Hamilton added 10 each.
Detroit's Ben Wallace remained out following the death of his brother last weekend, and Tracy McGrady, who has been benched, sat out for a fifth straight game. ... Washington attempted 34 free throws to Detroit's 14.