It was enough for the Heat to hold off the scrapping Bobcats 112-103.
"When we're aggressive, good things happen," Bosh said. "I think that showed our mentality was to attack today."
The victory, combined with Boston's 104-88 win over Washington, kept the Heat and Celtics tied for the second spot in the Eastern Conference with identical 55-24 records. They meet in Miami on Sunday, with the winner taking a huge step toward securing home-court advantage for the first two playoff rounds.
"Why not go get it?" James asked.
Added coach Erik Spoelstra: "Let's play."
Miami won for the 12th time in 15 games and swept four games with Charlotte this season. The Heat will get the East's No. 2 seed by winning out, and Spoelstra vowed his team would keep the focus Friday on Charlotte, not Boston or anyone else.
Down the stretch, the Bobcats insisted that be the case.
"We had a chance," Charlotte coach Paul Silas said.
He was right. D.J. White's tip-in with 1:29 left got Charlotte within 104-98, even though Miami took a 14-point lead into the fourth and held that same margin with 6 minutes to play.
The "Big 3" provided breathing room. Wade got the ball at midcourt, threw to Bosh, who then set up James for a basket with 1:09 left that made it a three-possession game. And James sealed it with 37 seconds left, finding Bosh with a sharply angled pass for a layup and a 108-100 lead.
"We just couldn't complete plays," Silas said. "But I am so proud of these guys to not give up and keep working hard. ... Just a great effort."
Miami moved to 14-0 when it has 25 or more assists. It had 26 assists against the Bobcats, along with 62 points in the paint and 31 more from the foul line.
Still, this outcome really wasn't decided until the final minute.
"We just ran out of energy," Brown said. "They had all of their guys."
Wade's status wasn't official until about 45 minutes before tipoff because of the deep bruise that he's battled for about a week in his right thigh. The way he came out, it was hard to tell anything was wrong.
His plan was to slowly work his way into a rhythm. Instead, he took over early, scoring 14 points in the first quarter, his third-highest total for an opening period this season, and attacking the rim enough to earn nine free throw tries in the first 5:53.
"He looked like he was caged for three days ... so aggressive and absolutely assaulting the rim," Spoelstra said. "That was good."
When he stopped scoring, James started, getting three field goals in a 75-second span -- the last of them a one-handed slam off an inbound pass from Mario Chalmers, who had just checked into the game. Miami was up 31-22, and signs pointed to a quick runaway.
Charlotte had other ideas.
It was a 41-38 game midway through the second quarter, and Miami needed a 10-4 run just to take a double-digit lead -- 55-44 -- into halftime.
The third quarter turned into a bit of a highlight show at times for the Heat, with Wade throwing a pair of full-court overhand passes to James and Miami running at every opportunity. Brown took exception at one point, leveling Wade with a flagrant-1 foul on a dunk try with 5:35 left in the third.
Every time Miami tried to run away, Charlotte answered, until time finally ran out.
So bring on Boston, which is 3-0 against Miami this season.
"We think we're a much different team than the three times we've played them," Spoelstra said.
Erick Dampier was introduced as Miami's starter at center, but Zydrunas Ilgauskas actually got the start and is the first-stringer "for now," Spoelstra said. ... Queen Latifah was among the celebrities in the building. ... Charlotte became the 11th team to get swept by Miami this season, joining Detroit, Golden State, Houston, the Lakers, Minnesota, New Jersey, Philadelphia, Phoenix, Sacramento and Washington. The Heat could also add Toronto to that list if they win in Canada on Wednesday.