Minnesota (3-2) was playing its first game since Love broke his hand in a training accident, putting him out of action for six to eight weeks.
Minnesota coach Rick Adelman said before the game that Cunningham and second-year forward Derrick Williams will vie for minutes during Love's absence. Williams was limited to five points in 23 minutes.
The Bulls jumped out to a 14-2 lead, hitting all six of their shots from the field. Minnesota attempted just three shots while committing four turnovers during Chicago's run.
Chicago built the lead to 15 points by halftime, with Boozer scoring 11 of his 18 first-half points in the second period.
The Bulls eventually led by as many as 18 points in the second half. Minnesota was unable to draw closer than 11 during the final period, when Chicago coach Tom Thibodeau put his starters back on the floor.