It was Anthony's second consecutive 30-point performance after going a season-high six straight games without reaching that mark. He averaged 22.5 points during that six-game stretch before breaking through for 30 on 11-of-19 shooting in a win over Oklahoma City on Wednesday, just hours after being treated for dehydration with intravenous fluids.
"That's what All-Stars do. That's why he puts up the numbers that he does," said Indiana's Danny Granger, who scored 32 points. "We just didn't have any answer for him."
Anthony, who has 25 games of 30-plus points this season, reached the milestone in back-to-back games for the first time since doing so in five straight from Dec. 8-16.
Anthony, who said he had been feeling run-down for about a week and a half, received additional intravenous fluids after Friday night's game, when he went 12 of 20 from the field and 9 of 10 from the free throw line.
"I felt much better," Anthony said after getting the latest round of IV fluids. "My legs are starting to get back. I had to get another one. That was for precautionary reasons."
Anthony said he wouldn't be surprised if he had to get more IV treatments in the coming days and weeks to help him hold up as the Nuggets make their playoff push.
"The way that we play, the way I play, the traveling, it can wear on anybody," he said. "The last week and a half, it's been wearing on me."
On Friday, he was wearing on the Pacers.
"Every time we started to climb back in, Carmelo just took over," Indiana coach Jim O'Brien said. "He is a terrific talent, no matter how closely you guard him. He makes shots. He just overpowers people. They have a heck of a basketball team."
J.R. Smith added 20 points off the bench and Chauncey Billups had 14 for the Nuggets, who sent the Pacers to their fifth loss in a row on the road.
Nene and Chris Andersen each added 13 points and they combined for 16 rebounds, helping to make up for the absence inside of Martin, who sat out with a recurrence of left knee tendinitis. Lawson, a key reserve, missed a third straight game with a bruised left shoulder.
While Anthony's big night was a huge factor for the Nuggets, it was their bench players who got them over the hump, combining for 48 points.
"They all did great," Denver guard Arron Afflalo said. "We needed that tonight and it was important for us."
The Nuggets have put together successive wins at the Pepsi Center after finishing their most recent road trip with back-to-back losses in Los Angeles and Phoenix, the first time they had dropped consecutive games since late December.
Trailing by eight at halftime, the Pacers pulled to 82-76 when Josh McRoberts dunked over Andersen with 4:03 remaining in the third. But the Nuggets closed the period with a 15-6 run, with Andersen muscling in a putback and then hustling down court to swat an attempted layup by Granger.
Anthony had seven points in the surge that carried the Nuggets to a 97-82 lead heading into the fourth quarter. They maintained a double-digit lead until the final moments of the game.
Smith hit a pair of 3-pointers in the last 90 seconds of the first, helping the Nuggets take a 38-28 lead. Denver appeared on the verge of running away with the game when it scored 12 of the next 17 points, moving in front 50-33 midway through the second quarter on consecutive dunks by Nene.
But the Pacers strung together a 10-0 run to pull to 52-45 and trailed 64-56 at halftime after Granger and Dahntay Jones each made a pair of free throws in final 47 seconds of the second quarter.
The Nuggets went 2-0 against the Pacers this season, their fourth series sweep in the last six years. ... Denver improved to 25-0 when scoring 110 or more points. ... Indiana has lost 10 of 12 to the Nuggets after winning 24 of the previous 29 meetings. ... Granger has 10 30-point performances this season, including his last four games. ... Smith had a career-high eight assists.