The school did not say Saturday what Sene did to merit the suspension.
Sene will miss the Cavaliers' season-opener again Longwood on Nov. 13, and games at South Florida and with Rider. He also will not play in a closed scrimmage with St. John's on Sunday.
The 7-foot Senegal native started 16 of the 22 games he played in last season. He averaged 2.5 points and 4.6 rebounds, and led the team with 35 blocked shots.
Coach Tony Bennett says he hopes Sene learns from the suspension.