Jeremiah Wood added 10 points and eight rebounds for the Zips (7-2).
St. Francis (4-6) scored the first basket but it was the only time it led during the game, and Akron had pulled to a 37-19 lead by halftime. The Zips' 35-point lead came with 8 seconds left to play and was their largest of the night.
Akron outshot St. Francis 43 percent to 25 percent overall and 42 percent to 27 percent on 3-pointers. St. Francis' 17 of 22 free throws led Akron's 9 of 13.