With the win, Stetson (6-12, 2-5 Atlantic Sun Conference) snapped its four-game losing streak.
Campbell (7-9, 2-4) entered the game averaging 85 points a game -- the best average in the conference. But Stetson held the Camels to 39.6 percent (21 of 53) shooting from the floor.
Jonathan Rodriguez scored a season-high 30 points and a game-high 12 rebounds for Campbell. Eric Smith finished the night with 11 points, and was the only other Camel who racked up a double-digit point total.
Stetson led 21-10 midway through the first half but Campbell left the court at halftime with a 32-30 lead.
Stetson recovered the lead early in the second half and never looked back after a 3-pointer by Gabe McMillen for a 36-34 edge at the 18:05 mark.
Campbell got within seven points of Stetson's lead when Rodriguez converted two free throws with 5 minutes left to play, but McMillen hit another 3-pointer to keep Stetson in front by 10 points with 4:35 left.
McMillen finished with 15 points and J.J. Hirst also had 10 points.