Sammy Mejia finished with 10 points for DePaul (13-10, 4-5 Big East), which stopped a three-game losing streak.
Connecticut (13-8, 2-6) has lost five straight, matching its longest losing streak since the 2000-01 season and are in danger of not making the Big East Tournament. The top 12 teams qualify for the tournament leaving out the remaining four teams. Currently, the Huskies, who won the Big East regular season championship last season, are tied for 13th place.
DePaul closed out the first half with a 12-2 run, then opened the second half by outscoring Connecticut 16-2.
Trailing 19-15, Burns scored eight points in the final 2:38 of the first half. He hit a jumper to tie the game and then broke a 19-all tie with a 3. After an alley-oop dunk pass to Chandler, Burns made a 3 as time expired to give DePaul a 27-21 lead at the break. Burns scored 13 points in the half on 5-of-9 shooting.
DePaul piled it on in the second half. Lorenzo Thompson and Mejia started the scoring for the Blue Demons with back-to-back 3's and Burns capped off the run with a putback to put DePaul up 43-23 with 14:41 to go.
Despite trailing by 20 in the second half, the Huskies made a game out of it. Price's basket cut the Blue Demons' lead to 55-44 with 4:17 left, he had a steal and layup to cut the lead to 57-50 with 2:00 remaining. Jerome Dyson picked Jabari Currie from behind for a layup to cut it to 57-54 with 1:29 to go, but DePaul answered with an alley-oop dunk from Chandler, making it 59-54.
Jerome Dyson led Connecticut with 15 points and Jeff Adrien finished with 10.
Craig Austrie's nine points on 4-of-4 shooting led the Huskies in the first half, during which Connecticut led 17-10 midway through. The Huskies held DePaul to 4-for-22 shooting to start the game. Austrie failed to score in the second half.