Drake (13-12, 4-10 Missouri Valley) built a six-point halftime lead and led the entire second half, completing a season sweep of the Panthers and breaking a 12-game losing streak in Cedar Falls.
Northern Iowa (16-9, 7-7) struggled from the perimeter, shooting 38.5 percent from the floor in the first half and 1-for-12 on 3-point-attempts.
After leading by five points in the opening minutes of the game, the Panthers fell behind 28-22 at halftime and trailed by 10 after Grant hit a jumper with 16:59 left in the game.
Drake held off a couple late rallies from Northern Iowa, including a 3-pointer from Brooks McKowen that cut the Bulldogs' lead to 60-57 with 2:27 left. Klayton Korver answered with consecutive baskets to seal the win.