The Cowboys (1-2) scored 15 of the game's first 17 points to hold a 15-2 lead at the 12:45 mark. Paced by strong three-point shooting, Louisiana College (0-1) rallied to cut the lead to 24-20 with 5:12 to go in the first half.
McNeese then went on an 8-2 run to close out the half with a 32-22 lead.
In the second half, McNeese pulled away and was up by 33 points at the 7:45 mark, going on to win by 20.
The Cowboys held a 48-22 edge in rebounding, with Bradley and P.J. Alawoya leading the way with seven each and Penn getting six.
Louisiana College did not have a double-figure scorer. Daniel Greenhouse scored nine to lead the team while Dustin Cole had eight and Jeremy Hollier seven.