Rush set an Allstate Arena record by making 10 3-pointers in the game and the Aggies set the arena team record with 17 3-pointers.
Leading 58-53 with 15:40 left, Rush sparked North Carolina A&T (4-2) by scoring eight straight points. He hit a 3, then made a jumper. Rush then had the DePaul (1-2) fans in shocked when he hit a 3, well beyond the 3-point arc.
Thomas Coleman gave the Aggies a 68-53 lead with a dunk with 13:10 left.
DePaul freshman Dar Tucker's 3-point attempt to tie the game missed as time expired.
Cliff Clinkscales hit a 3 for DePaul to cut the lead to 87-82 with 2:55 left, but Ewing answered with another 3 for the Aggies.
DePaul got within 91-89 on Draelon Burns jumper with 48.3 seconds left but the Aggies came back with three free throws.
Burns finished with 32 points and Tucker added 20 for DePaul.
The Aggies led 48-45 at the half after trailing 34-18 midway through the half. They came back by scoring 16 straight points on five 3-pointers.
Ewing and Rush each hit two 3's during the span. Ewing's second 3 tied the game at 34 with 7:07 left in the half and Rush put the Aggies up 46-41 with 2:01 left. Rush scored 17 points in the half on 5-of-9 shooting from 3-point range.
Burns led DePaul with 20 points in the first half on 5-of-10 shooting.